Work

Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging

Year: 2022

Type: article

Abstract: We report MRI tools to measure and map single-nephron function in the isolated, perfused rat kidney. We used imaging tracers to identify nephrons throughout the kidney and to measure the delivery and filtration of the tracers at the location of the glomeruli. With this technique, we directly measured physiological parameters including estimated single-nephron glomerular filtration rate throughout the kidney. This work provides a foundation for new studies to simultaneously map the function of large numbers of nephrons.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00103.2022

Authors: Edwin J. Baldelomar, Jennifer R. Charlton, Kevin M. Bennett

Institutions: Washington University in St. Louis, University of Virginia

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Virginia, School of Medicine, University of Virginia, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences