Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF
Year: 2022
Type: article
Abstract: We performed a comprehensive assessment to evaluate the effects of slow progressive pressure overload on cardiopulmonary function in a large animal model of heart failure with preserved ejection fraction (HFpEF) in males and females. Functional and structural assessments were performed at the organ, tissue, cellular, protein, and transcriptional levels. This is the first study to compare snRNAseq and ECM mass spectrometry of HFpEF myocardium from males and females. The results broaden our understanding of the pathophysiological response of both sexes to pressure overload. Both sexes developed a robust cardiopulmonary phenotype, but the phenotype was equal or a bit less robust in females.
Authors: Deborah M. Eaton, Remus M. Berretta, Jacqueline E. Lynch, Joshua G. Travers, Ryan D. Pfeiffer, Michelle L. Hulke, Huaqing Zhao, Alexander R. H. Hobby, Giana Schena, Jaslyn P. Johnson, Markus Wallner, Edward Lau, Maggie P. Y. Lam, Kathleen C. Woulfe, Nathan R. Tucker, Timothy A. McKinsey, Marla R. Wolfson, Steven R. Houser
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1394805379, G1728756057, G2200511125, G2451848122, G2635073672, G3023913720, G3380712950, Deacetylase-Dependent Control of Diastolic Dysfunction and HFpEF, G442848922, G4846153411, Epigenetic Readers as Downstream Effectors of Beta1-Adrenergic Receptor Signaling in HFrEF, G7303409340, Sex-specific regulation of myofibrillar function in the aging heart, G7467406568, G7683404682, G8640457342, G8968453874
OpenAlex ID: W4294300847