Work

Mechanical response of cardiac microtissues to acute localized injury

Year: 2022

Type: article

Abstract: We report an in vitro cardiac injury model that uses a high-powered laser to induce regional cell death and a focal fibrotic response within a human-engineered cardiac microtissue. The model captures the effects of acute injury on tissue response, remodeling, and electromechanical recovery in both the damaged region and surrounding healthy tissue, modeling similar changes to contractile function observed in vivo following myocardial infarction.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00305.2022

Authors: Shoshana L. Das, Bryan P. Sutherland, Emma Lejeune, Jeroen Eyckmans, Christopher S. Chen

Institutions: Boston University, Harvard University, Wyss Institute for Biologically Inspired Engineering, Massachusetts Institute of Technology

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, American Heart Association, National Institute of Biomedical Imaging and Bioengineering