Work

XL-ing at Induction of Apoptosis in Kidney Cancer through Inhibition of BCL-XL

Year: 2022

Type: article

Abstract: Through analysis of the cancer dependency map of CRISPR and short hairpin RNA datasets, the antiapoptotic BCL-XL was found to be a selective dependency in kidney cancer. Among kidney cancers, BCL-XL inhibition is most active in those with a mesenchymal gene signature, which portends a poor prognosis and response to current therapies. See related article by Grubb et al., p. 4689.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-22-2104

Authors: Naitao Wang, A. Ari Hakimi, Yu Chen

Institutions: Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute