Work

Extracellular vesicles and Alzheimer’s disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment

Year: 2022

Type: article

Abstract: Extracellular vesicles (EVs), secreted membranous nano-sized particles, are critical intercellular messengers participating in nervous system homeostasis, while recent evidence implicates EVs in Alzheimer's disease (AD) pathogenesis. Specifically, small EVs have been shown to spread toxic proteins, induce neuronal loss, and contribute to neuroinflammation and AD progression. On the other hand, EVs can reduce amyloid-beta deposition and transfer neuroprotective substances between cells, mitigating disease mechanisms. In addition to their roles in AD pathogenesis, EVs also exhibit great potential for the diagnosis and treatment of other brain disorders, representing an advantageous tool for Precision Medicine. Herein, we summarize the contribution of small EVs to AD-related mechanisms and disease progression, as well as their potential as diagnostic and therapeutic agents for AD.

Source: Experimental Neurology

DOI: 10.1016/j.expneurol.2022.114183

Authors: Patrícia Gomes, Foteini Tzouanou, Konstantina Skolariki, Anastasia Vamvaka-Iakovou, Carlos Noguera-Ortiz, Katerina Tsirtsaki, Clarissa L. Waites, Panagiotis Vlamos, Nuno Sousa, Bruno Costa-Silva, Dimitrios Kapogiannis, Ioannis Sotiropoulos

Institutions: University of Minho, National Centre of Scientific Research "Demokritos", Institute of Biosciences & Applications, Ionian University, National Institutes of Health, National Institute on Aging, Columbia University Irving Medical Center, Columbia University, Centro Champalimaud

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,810

Funders: National Institutes of Health, Fundação para a Ciência e a Tecnologia, European Regional Development Fund, National Institute on Aging

Awards: G1167214205, G1516346500, G1578237752, G1713655041, G1763632427, G2260414028, G2440504136, G274581676, G2838476969, G323769159, G3326568298, G3525276842, ICVS/3B’s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos, G3786582701, G3840324753, G4316116677, Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases (FROnTHERA), G4425158674, G4724859719, New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders – “PersonalizedNOS”, G5224927334, Projecto Estratégico - LA 26 - 2013-2014, G5454278309, G5677667711, UID/Multi/50026 .: ICVS/3B?s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Bio, G7378191761, G7423759087, G7584003722, G7965899483, G8757879299, G8868700560, ALZHEIMERS RESEARCH PROJECT / CLINICAL PROJECT: Mechanistic and clinical studies in Alzheimer's disease and related disorders, G96847669

OpenAlex ID: W4294553463

FWCI: 2.898

Cites: 257

Cited by: 55

Related to: 10