Year: 2022
Type: article
Study design: Observational Study
Abstract: hocks to supply chains triggered by the COVID-19 pandemic and a COVID-19-driven shutdown of a manufacturing facility in Shanghai, China, have resulted in a severe and unanticipated shortage in iodinated contrast media (ICM).To address this challenge, radiology and other specialties using contrast agents have been called on to prioritize indications for and conserve use of ICM. 1 Steps to prioritize indications and conserve contrast have the potential to restrict access to stenting for patients with asymptomatic atherosclerotic carotid stenosis.In addition to adversely affecting clinical practice, an ICM shortage has the potential to compromise enrollment into clinical trials of revascularization.CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial) includes randomization to stenting versus intensive medical management. 2 CREST-2 leadership was particularly concerned about the effects of ICM shortage because in recent years, enrollment has been slower in the stenting trial than in the endarterectomy trial.As of June 6, 2022, a total of 973 patients have been enrolled in the stenting trial and 1101 in the endarterectomy trial.The purpose of this study was to gain insights into how the ICM shortage was affecting CREST-2 investigators.Data are available upon request to the corresponding author.The reporting guideline used was the Standards for Reporting Qualitative Research.3 CREST-2 has 143 clinical performance sites across the United States, Canada, and Spain.On May 12, 2022, the CREST-2 Clinical Coordinating Center electronically mailed a 2-question pulse survey to CREST-2 physician investigators.The survey was closed to responses on
Authors: James F. Meschia, Brajesh Lal, Thomas G. Brott
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,300
OpenAlex ID: W4294756182