Work

Simultaneous quantification of blood rheology and oxygen saturation to evaluate affinity-modifying therapies in sickle cell disease

Year: 2022

Type: article

Abstract: saturation is reached to observe pathological blood flow. These results help explain the mechanistic effects of voxelotor and show the potential of this platform to identify affinity-modifying compounds and evaluate their therapeutic effect on blood flow.

Source: Lab on a Chip

DOI: 10.1039/d2lc00623e

Authors: Scott Hansen, David K. Wood

Institution: University of Minnesota

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Heart, Lung, and Blood Institute, Division of Electrical, Communications and Cyber Systems