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Advances toward transformative therapies for tendon diseases

Year: 2022

Type: article

Abstract: Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies. Shifting from targeting symptom relief toward disease modification and prevention of disease progression may open new avenues for therapies. Deep evidence-based clinical, cellular, and molecular characterization of the underlying pathology of tendon diseases, as well as therapeutic delivery optimization and establishment of multidiscipline interorganizational collaboration platforms, may accelerate the discovery and translation of transformative therapies for tendon diseases.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.abl8814

Authors: Benjamin R. Freedman, David J. Mooney, Eckhard Weber

Institutions: Harvard University, Wyss Institute for Biologically Inspired Engineering, Novartis (Switzerland)

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging