Uncovering a tripartite landmark in posterior cingulate cortex
Year: 2022
Type: article
Abstract: ABSTRACT Understanding brain structure-function relationships, and their development and evolution, is central to neuroscience research. Here, we show that morphological differences in posterior cingulate cortex (PCC), a hub of functional brain networks, predict individual differences in macroanatomical, microstructural, and functional features of PCC. Manually labeling 4,319 sulci in 552 hemispheres, we discovered a consistently localized shallow cortical indentation (termed the inframarginal sulcus; ifrms ) within PCC that is absent from neuroanatomical atlases, yet co-localized with a region within the cognitive control, but not default mode, network. Morphological analyses in humans and chimpanzees showed that unique properties of the ifrms differ across the lifespan and between hominoid species. Intriguingly, the consistency of the ifrms also debunks the uniqueness of the morphology of Einstein’s PCC. These findings support a classic theory that shallow, tertiary sulci serve as landmarks in association cortices. They also beg the question: how many other cortical indentations have we missed?
Source: Science Advances
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Funders: National Science Foundation, U.S. Department of Defense, Alzheimer's Association, Bristol-Myers Squibb, Biogen, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Eisai, National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1554142629, G1650819308, CAREER: Unique brain structures in human cortex: From structure to function and cognition, G2189010064, G2340207221, G2423387114, G2835601961, G29951154, G3131374986, G3216574877, Collaborative Research: The Role of Brain Connectivity in Reasoning Development, G3553156159, G3594245266, G4119534169, G43180419, A National Chimpanzee Brain Resource, G4475667458, G4800177743, G5207404921, G5324093878, G5654639750, G5850682332, G598818333, G6210868510, G6371410416, G6671297155, G6792506723, G6899163935, G7268282379, The role of prefrontal sulcal morphology and brain network architecture in cognitive development, G764699806, G8228018387, G8301434335, Multimodal dissociation of posterior cingulate cortex contributions to episodic memory, G8895907669, Posterior cingulate cortex and executive control of episodic memory, Neuroscience Training Program at UC Berkeley
OpenAlex ID: W4294884857