Work

Evaluating the Breadth of Neutralizing Antibody Responses Elicited by Infectious Bursal Disease Virus Genogroup A1 Strains Using a Novel Chicken B-Cell Rescue System and Neutralization Assay

Year: 2022

Type: article

Abstract: There is a need to evaluate the ability of vaccines to neutralize diverse IBDV genogroups and to better understand the relationship between HVR sequence, structure, and antigenicity. Here, we used a chicken B-cell line to rescue a panel of chimeric IBDVs with the HVR from seven diverse IBDV field strains and to conduct neutralization assays and protein modeling.

Source: Journal of Virology

DOI: 10.1128/jvi.01255-22

Authors: Vishwanatha R. A. P. Reddy, Salik Nazki, Andrew J. Brodrick, Amin Asfor, Joanna Urbaniec, Yasmin Morris, Andrew J. Broadbent

Institutions: The Pirbright Institute, University of Maryland, College Park, University of Surrey

Language: English

Topic: Animal Virus Infections Studies

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: UK Research and Innovation, Directorate for Biological Sciences, Biotechnology and Biological Sciences Research Council

Awards: G1369978484, G1713228754, Molecular and Systems Virology, Science Services, G3196586316, Antigenic characterisation of infectious bursal disease virus to improve vaccination strategies and vaccine design, G627537242, Fellowship in IBDV research, G7683857344

OpenAlex ID: W4294921245

FWCI: 1.734

Cites: 55

Cited by: 13

Related to: 10