Work

Redox-Mediated Inactivation of the Transcriptional Repressor RcrR is Responsible for Uropathogenic Escherichia coli’s Increased Resistance to Reactive Chlorine Species

Year: 2022

Type: article

Abstract: How do pathogens deal with antimicrobial oxidants produced by the innate immune system during infection? Uropathogenic Escherichia coli (UPEC), the most common etiological agent of urinary tract infections (UTIs), is particularly exposed to infiltrating neutrophils and, therefore, must counter elevated levels of the antimicrobial oxidant HOCl to establish infection. Our study provides fundamentally new insights into a defense mechanism that enables UPEC to fend off the toxic effects of HOCl stress.

Source: mBio

DOI: 10.1128/mbio.01926-22

Authors: Sadia Sultana, Mary E. Crompton, Kennadi Meurer, Olivia Jankiewicz, Grace H. Morales, Colton Johnson, Elise Horbach, Kevin Pierre Hoffmann, Pooja Kr, Ritika Shah, Greg M. Anderson, Nathan T. Mortimer, Jonathan E. Schmitz, Maria Hadjifrangiskou, Alessandro Foti, Jan-Ulrik Dahl

Institutions: Illinois State University, Vanderbilt University Medical Center, Vanderbilt University, Max Planck Institute for Infection Biology

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Vanderbilt University, Illinois State University, Deutscher Akademischer Austauschdienst, Directorate for Biological Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Redox-regulation in Gram-negative Bacteria, The Vanderbilt Urologic Infection Repository, a Resource for Personalized Clinical Discovery

OpenAlex ID: W4294992992

FWCI: 2.83

Cites: 110

Cited by: 24

Related to: 10