Cold Laser Micro-Machining of PDMS as an Encapsulation Layer for Soft Implantable Neural Interface
Year: 2022
Type: article
Abstract: PDMS (polydimethylsiloxane) is an important soft biocompatible material, which has various applications such as an implantable neural interface, a microfluidic chip, a wearable brain-computer interface, etc. However, the selective removal of the PDMS encapsulation layer is still a big challenge due to its chemical inertness and soft mechanical properties. Here, we use an excimer laser as a cold micro-machining tool for the precise removal of the PDMS encapsulation layer which can expose the electrode sites in an implantable neural interface. This study investigated and optimized the effect of excimer laser cutting parameters on the electrochemical impedance of a neural electrode by using orthogonal experiment design. Electrochemical impedance at the representative frequencies is discussed, which helps to construct the equivalent circuit model. Furthermore, the parameters of the equivalent circuit model are fitted, which reveals details about the electrochemical property of neural electrode using PDMS as an encapsulation layer. Our experimental findings suggest the promising application of excimer lasers in the micro-machining of implantable neural interface.
Source: Micromachines
DOI: 10.3390/mi13091484
Institutions: Fudan University, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education, Ji Hua Laboratory, Chinese Academy of Sciences, Changchun Institute of Optics, Fine Mechanics and Physics, State Key Laboratory of Applied Optics, Zhejiang Lab
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,094
Awards: G1301064832, G1304539524, G1305117808, G1415410481, G1503850533, G1543926861, G1614680784, G181997071, G1926475483, G1934945128, G1965983432, G2022062133, G2087882579, G2099786747, G2131163949, G231848252, G2348885218, G2431536558, G2457548366, G2533950751, G255160342, G269866877, G2787663095, G296198563, G3125932999, G3208788829, G3351285525, G3451584290, G3520359106, G3603046598, G3867487915, G3920411881, G3955273678, G4321700915, G4369120348, G5154848714, G5375933565, G5481929365, G5495614398, G5514114845, G552782032, G5549592584, G5574148142, G6131199608, G6242096479, G6244745179, G6265710886, G6271259443, G6300311230, G6331850339, G64899366, G6758385550, G7223888415, G7313064630, G7546137549, G7717894756, G7865240111, G7937426765, G7997179098, G8043359214, G8260978993, G8274730919, G8299876865, G8494586185, G8575818762, G8712293185, G8788150448, G8899475930, G8904538476, G929844129, G930581541
OpenAlex ID: W4295007899