Work

Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC–MS/MS Approach

Year: 2022

Type: article

Source: Analytical Chemistry

DOI: 10.1021/acs.analchem.2c03146

Authors: Lingyao Meng, Emily W. Chan, Carl Ng, Junko Aimi, John C. Tran, Angela J. Oh, Mark Merchant, Hans E. Purkey, Timothy P. Heffron, Surinder Kaur, Keyang Xu, Zhen Shi, Jintang He

Institution: Genentech

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W4295038037

FWCI: 0.976

Cites: 14

Cited by: 15

Related to: 10