Work

Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype

Year: 2022

Type: article

Abstract: Enterococcus faecalis is a leading cause of health-care-associated infections for which there are limited treatment options. E. faecalis is resistant to several antibiotics and to high concentrations of the human antimicrobial enzyme lysozyme. The molecular mechanisms that mediate lysozyme resistance in E. faecalis are complex and remain incompletely characterized.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00247-22

Authors: Candace N. Rouchon, Arielle J. Weinstein, Carissa A. Hutchison, Zahra B. Zubair-Nizami, Petra L. Kohler, Kristi L. Frank

Institutions: Henry M. Jackson Foundation, Uniformed Services University of the Health Sciences, University of Minnesota

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green