Year: 2022
Type: article
Study design: Case Report
Abstract: To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
Source: npj Parkinson s Disease
Institution: University of Minnesota
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
Awards: G1659947613, University of Minnesota Clinical and TranslationalmScience Institute (UMN CTSI), G3573251375, Circuit-based deep brain stimulation for Parkinson's disease, G5118616669, NMR Imaging and Spectroscopy, Optimizing coordinated reset deep brain stimulation for Parkinson's disease, Institutional Center Cores for Advanced Neuroimaging, Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey, G9000308991, G9000338996, G9000351955, The effects of parkinsonism and deep brain stimulation on basal ganglia-thalamocortical circuitry during sleep-wake behavior, Circuit-based deep brain stimulation for Parkinson's disease, Technology to Realize the Full Potential of UHF MRI, Sleep-specific DBS therapy in Parkinson's disease, Neurophysiological Mechanisms Underlying Parkinsonian Motor Signs, Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS
OpenAlex ID: W4295350565