Work

Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study

Year: 2022

Type: article

Study design: Observational Study

Abstract: In this study, we showed that the proinflammatory cytokine response in SAP is an early event, with subsequent downregulation of proinflammatory cytokines beginning at day 1 of symptom onset. Our findings underscore the importance of enrolling subjects very early in the disease course when conducting studies to investigate early immune events of SAP; this current study also serves as an important reference for the design of future biomarker studies and therapeutic trials in SAP.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00100.2022

Authors: Phil J. Greer, Peter J. Lee, Pedram Paragomi, Kim Stello, Anna Phillips, Phil Hart, Cate Speake, Adam Lacy-Hulbert, David C. Whitcomb, Georgios I. Papachristou

Institutions: The Ohio State University Wexner Medical Center, University of Pittsburgh, Benaroya Research Institute

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G17032430, NAPS2 Continuation - Genome-Wide Association Study of Pancreatitis, MECHANISM OF SYSTEMIC INFLAMMATION-ASSOCIATED ENDOTHELIAL AND EPITHELIAL CELL DYSFUNCTION FOLLOWING ACUTE PANCREATITIS, TRAUMA, AND BURNS, ACUTE PANCREATITIS AS A MODEL TO PREDICT TRANSITION OF SYSTEMIC INFLAMMATION TO ORGAN FAILURE IN TRAUMA AND CRITICAL ILLNESS, NAPS2 Continuation Genome Wide Association Study of Pancreatitis, G7789533362

OpenAlex ID: W4295366622

FWCI: 4.666

Cites: 53

Cited by: 29

Related to: 10