High Unreported Mortality in Children and Youth (<25 Years) Living With HIV Who Were Lost to Care From Antiretroviral Therapy Programs in Southern Africa: Results From a Multicountry Tracing Study
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Antiretroviral therapy program mortality maybe underestimated if deceased patients are misclassified as lost. METHODS: We used two-stage inverse probability weighting to account for probability of being: sampled for tracing and found by the tracer. RESULTS: Among 680 children and youth aged <25 years on antiretroviral therapy who were lost and traced in Southern Africa between October 2017 and November 2019, estimated mortality was high at 9.1% (62/680). After adjusting for measured covariates and within-site clustering, mortality remained lower for young adults aged 20-24 years compared with infants aged <2 years [adjusted hazard ratio: 0.40 (95% confidence interval: 0.31 to 0.51)]. CONCLUSIONS: Our study confirms high unreported mortality in children and youth who are lost and the need for tracing to assess vital status among those who are lost to accurately report on program mortality.
Authors: Patience Nyakato, Benedikt Christ, Nanina Anderegg, Josephine Muhairwe, Laura Jefferys, Janneke van Dijk, Michael J. Vinikoor, Monique van Lettow, Cleophas Chimbetete, Sam J. Phiri, Matthias Egger, Marie Ballif, Constantin T. Yiannoutsos, Michael Schomaker, Reshma Kassanjee, Mary-Ann Davies, Morna Cornell, on behalf of International epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA-SA)
Institutions: University of Cape Town, Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Bern, SolidarMed, Centre for Infectious Disease Research in Zambia, Dignitas International, Lighthouse Trust, Indiana University Indianapolis, Ludwig-Maximilians-Universität München
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G2542180245, G2606189360, G3475612999, Stetige Interventionen in der Epidemiologie: von der Theorie zur Praxis, Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Kausale Inferenz für stetige longitudinale Interventionen in der Epidemiologie, G5522199286, G596821015, G9000052486
OpenAlex ID: W4295441402