Association of follistatin and cytochrome p450 side-chain cleavage enzyme with polycystic ovarian syndrome.
Year: 2022
Type: article
Study design: Observational Study
Abstract: Objectives: Polycystic ovarian syndrome is a complex disorder commonly found in women in their reproductive age around the globe. Due to its higher clinical implications and communicability, this research article describes epidemiological studies and the association of known microsatellite markers with PCOS in the Pakistani population. Methods: Data were collected from 62 Pakistani women. The study involved pedigree analysis which revealed recessive mode of inheritance in all of them. The mendelian ratio in marriages between non-PCOS (male) and PCOS (female) individuals remained 1:1 while between non-PCOS (male) and non-PCOS (female) remained 3:1, respectively. Results: ≥ 0.05). Conclusion: Findings indicated a higher prevalence of PCOS and highlights the emergence of more interventions to minimize the level of complications in women. Our intrusions intended to describe the genetic basis of PCOS in Pakistani population with special emphasis on large families in current study. Moreover, association of known loci for PCOS with our families.
Source: PubMed Central
Authors: Fouzia Nazir, S Inayatullah, S Jalali
Institutions: Hazara University, Quaid-i-Azam University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4295760576