Work

Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation

Year: 2022

Type: article

Study design: Observational Study

Abstract: Interstitial collagen loss and cardiomyocyte ultrastructural damage accounts for left ventricular (LV) sphericity and decrease in LV twist and circumferential strain. Normal LV diastolic function belies significantly abnormal left atrial (LA) function and early LV diastolic untwist rate. This underscores the complex interplay of LV and LA myocardial remodeling and function in the pathophysiology of primary mitral regurgitation. In this study, we connect LA function with LV systolic and diastolic myocardial remodeling and function using cardiac magnetic resonance tissue tagging in primary mitral regurgitation.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2022.04.014

Authors: Mustafa I. Ahmed, Efstathia Andrikopoulou, Jingyi Zheng, Elena Ulasova, Betty Pat, Eric E. Kelley, Pamela Cox Powell, Thomas S. Denney, Clifton Lewis, James E. Davies, Victor Darley-Usmar, Louis J. Dell’Italia

Institutions: University of Alabama at Birmingham, Auburn University, Birmingham VA Medical Center, West Virginia University

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: G1252336394, Vaso-Hormonal Mechanisms in Hypertension, Role of Xanthine Oxidase in Heme-induced Vascular Dysfunction, G2953880174, G3282005225, G502068938, G5849888855, G7403033301, Protective Role for Xanthine Oxidase in Heme-Induced Vascular Injury, G8188158628, G9000035654, G9000038536, G9000040110, G9000042556

OpenAlex ID: W4295777922

FWCI: 2.636

Cites: 30

Cited by: 15

Related to: 10