Curcumin prevents Alzheimer's disease progression by upregulating JMJD3.
Year: 2022
Type: article
Abstract: study, the levels of JMJD3, the mRNA and protein levels of BDNF in the right brain tissues of AD mice were downregulated, the methylation of H3K27me3 increased, and the MSR markers (ClpP, HSP6, HSP-60, ATFS-1, etc.) were downregulated; the above indexes were improved in varying degrees with the intervention of CUR. Thus, we conclude that CUR can induce the upregulation of JMJD3 and improve BDNF expression by promoting the demethylation of H3K27me3, thereby maintaining the balance of MSR and thus, preventing AD development.
Source: PubMed Central
Authors: Yutong Wang, Hong Zhang, Linlin Hua, Zhen Wang, Shuang Geng, Hui Zhang, Zhilei Zeng, Jing Zhao, Xiaoyan Wang, Yunliang Wang
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4295900176