Higher benefit-risk ratio of COVID-19 vaccination in patients with schizophrenia and major depressive disorder versus patients with bipolar disorder when compared to controls.
Year: 2022
Type: article
Study design: Observational Study
Abstract: Patients with major psychiatric disorders (MPD) that include schizophrenia (SCH), bipolar disorder (BP), and major depressive disorder (MDD) are at increased risk for coronavirus disease 2019 (COVID-19). However, the safety and efficacy of COVID-19 vaccines in MPD patients have not been fully evaluated. This study aimed to investigate adverse events (AEs)/side effects and efficacy of COVID-19 vaccines in MPD patients. This retrospective study included 2034 patients with SCH, BP, or MDD who voluntarily received either BBIBP-CorV or Sinovac COVID-19 vaccines, and 2034 matched healthy controls. The incidence of AEs/side effects and the efficacy of COIVD-19 vaccinations among the two groups were compared. The risk ratio (RR) of side effects in patients with MPD was 0.60 (95% confidence interval [CI]: 0.53-0.68) after the first dose and 0.80 (95% CI: 0.65-0.99) following the second dose, suggesting a significantly lower risk in the MPD group versus healthy controls. The RRs of AEs did not differ between patients and controls. Notably, fully vaccinated patients exhibited a decreased risk of influenza with or without fever compared with controls (RR=0.38, 95% CI: 0.31-0.46; RR=0.23, 95% CI: 0.17-0.30; respectively). Further subgroup comparisons revealed a significantly lower risk of influenza with fever in MDD (RR=0.13, 95% CI: 0.08-0.21) and SCH (RR=0.24, 95% CI: 0.17-0.34) than BP (RR=0.85, 95% CI: 0.69-1.06) compared to controls. We conclude that the benefit-risk ratio of COVID-19 vaccination was more favorable in SCH or MDD versus BP when compared with controls. These data indicate that COVID-19 vaccines are safe and protective in patients with MPD from COVID-19.
Source: PubMed
Authors: Jingjing Zhu, Hongjun Tian, Haibo Wang, Haiping Yu, Chuanxin Liu, Lina Wang, Qianchen Li, Tao Fang, Feng Jia, Yachen Li, Ranli Li, Xiaoyan Ma, Yun Sun, Jing Ping, Ziyao Cai, Deguo Jiang, Langlang Cheng, Min Chen, Sha Liu, Yong Xu, Qingying Xu, Guangdong Chen, Wei Liu, Waihui Yue, Xueqin Song, Chuanjun Zhuo
Institutions: Wenzhou Seventh People's Hospital, Nankai University, Tianjin Fourth Central Hospital, Tianjin Fourth Hospital, Peking University, Peking University First Hospital, Jining Medical University, Shanxi Medical University, First Hospital of Shanxi Medical University, Harbin University, Peking University Sixth Hospital, First Affiliated Hospital of Zhengzhou University, Tianjin Anding Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4295904287