Year: 2022
Type: article
Abstract: Structural biologists are undertaking increasingly challenging projects including the study of membrane proteins and complex multi-component machines. Structural investigations are also transitioning beyond solving a single static structure, to the application of a series of sequential structural snapshots to provide details of the atomic positions and motions that define the relationships involved in molecular recognition, transition state stabilization, and other aspects of the biocatalytic process. The success of these experiments requires careful optimization of samples and experimental setups, often involving multiple experiments at the laboratory bench and the beamline, where automation serves as an enabling technology to efficiently deliver multiple crystals and meet stringent timing requirements.
Author: Aina Cohen
Institution: SLAC National Accelerator Laboratory
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4295941241