Year: 2022
Type: article
Abstract: Single particle cryo-EM has become a mainstream structural biology tool due to its ability to solve high-resolution structures of biomolecules.However, many software for data processing in cryo-EM do not provide a user-friendly modern GUI or any GUI at all.Besides, it is not easy to process data with multiple tools which belong to different software packages in one pipeline.These result in a lack of motivation for most users to try new data processing tools.Here, we presented a software, cryoHub, whose goal is to build a highly customizable web interface for existing cryo-EM data processing tools.For the users, cryoHub aims to provide a web-based GUI to run and manage projects and jobs.For the method developers, cryoHub is an "engine" to enable a web-based GUI with minimum efforts.With React as the frontend framework and Node.js for the backend, cryoHub provides a GUI for any command-line based tool simply by configuring each individual command to a YAML file.Moreover, the webbased GUI also enables us to integrate more advanced data visualization widgets.We believe that cryoHub has the potential to bring the users closer to more "third-party" data processing tools in cryo-EM.
Authors: Yilai Li, Benjamin Walls, Han Liu, Le Yang, Rong Xiao, Chuteng Li, Zhehao Chen, Chuck Lugai, Michael Cianfrocco
Language: English
Subfield: Structural Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4295955754