Editorial: Current challenges in inflammation and pain biology: The role of natural and synthetic compounds
Year: 2022
Type: editorial
Abstract: Editorial on the Research Topic Current challenges in inflammation and pain biology: The role of natural and synthetic compounds Inflammation and pain are complex physiological responses which can evolve to chronic disorders.They involve an intricate network of molecules and receptors (Chen et al., 2018;Yam et al., 2018), often making their management, a clinical challenge.The discovery and development of natural and synthetic compounds with analgesic and/or anti-inflammatory activities have highly contributed to halt or attenuate different types of painful and inflammatory diseases (Atanasov et al., 2021;Beck et al., 2022).Their side effects, of special concern in chronic pathologies, prompted an increasing number of nonclinical and clinical studies aiming at evaluating the effectiveness and safety of novel natural and synthetic products for treating inflammation and pain.However, the costs involved in developing and implementing new therapies and the several challenges encountered including low selectivity, high incidence of adverse effects and/or unfavourable pharmacokinetics properties of drug candidates have been major setbacks in the field (Tautermann, 2020).These, highlight the need for novel studies focused on the discovery and development of analgesic and anti-inflammatory drugs.This Research Topic brings together senior researchers, clinicians, and researchers, to share science and hopes to treat inflammatory and painful disorders.Eight articles were published in the Current Challenges in Inflammation and Pain Biology: The Role of Natural and Synthetic Compounds Research Topic; these have been viewed more than 12,000 times.The articles published in this collection provided new information on diverse pathologies, including nephropathy, dermatitis, rheumatoid
Source: Frontiers in Physiology
Institutions: Universidade de São Paulo, Emory University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4295980940