Work

Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects

Year: 2022

Type: review

Abstract: Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson's disease, demonstrates beneficial effects in patients with hypertrophic cardiomyopathy. This review aims to present the updated development of the roles of trientine in hypertrophic cardiomyopathy. The drug has been demonstrated in animal studies to restore myocardial intracellular copper content. However, its mechanisms for improving the medical condition remain unclear. Thus, comprehending its mechanistic aspects in cardiomyopathy is crucial and could help to expedite future research.

Source: Pharmaceuticals

DOI: 10.3390/ph15091145

Authors: Fitri Fareez Ramli, Syed Alhafiz Syed Hashim, Betty Raman, Masliza Mahmod, Yusof Kamisah

Institutions: Warneford Hospital, University of Oxford, National University of Malaysia, John Radcliffe Hospital

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,094