Work

Author response: Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

Year: 2022

Type: peer-review

Abstract: Mutagenesis and activity assays in vitro and in vivo identify residues in the tethered agonist of GPR116, as well as those within the extracellular loops, that are critical for mediating the response to the tethered agonist.

Source: eLife

DOI: 10.7554/elife.69061.sa2

Authors: James P Bridges, Caterina Safina, Bernard Pirard, Kari Brown, Alyssa Filuta, Ravichandran Panchanathan, Rochdi Bouhelal, Nicole Reymann, Sejal Patel, Klaus Seuwen, William E Miller, Marie-Gabrielle Ludwig

Institutions: Cincinnati Children's Hospital Medical Center, Novartis (Switzerland), Novartis Institutes for BioMedical Research, University of Cincinnati

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4296510376

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