Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013
Year: 2013
Type: article
Abstract: Novel influenza viruses of the H7N9 subtype have infected 33 and killed nine people in China as of 10 April 2013. Their haemagglutinin (HA) and neuraminidase genes probably originated from Eurasian avian influenza viruses; the remaining genes are closely related to avian H9N2 influenza viruses. Several characteristic amino acid changes in HA and the PB2 RNA polymerase subunit probably facilitate binding to human-type receptors and efficient replication in mammals, respectively, highlighting the pandemic potential of the novel viruses.
Source: Eurosurveillance
Authors: T Kageyama, S Fujisaki, E Takashita, H Xu, S Yamada, Y Uchida, G Neumann, T Saito, Y Kawaoka, M Tashiro
Institutions: National Institute of Infectious Diseases, Institute of Medical Science, The University of Tokyo, The University of Tokyo, National Agriculture and Food Research Organization, National Institute of Animal Health, University of Wisconsin–Madison, Gifu University, Japan Science and Technology Agency
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4296590891