Year: 2022
Type: editorial
Abstract: Editorial on the Research Topic Alternative antigen processing and presentation in immune disordersThe key players and processes of the MHC class I and class II pathways were described decades ago and are essential to develop an efficient T cell response.However, they are not confined to canonical pathways only.Indeed, cross-presentation and autophagy are non-canonical processes that allow the presentation of peptides by MHC-I and MHC-II molecules that originate from proteins located in the endocytic or endogenous compartments, respectively.In addition, the structural features of the MHC-peptide interaction were described decades ago.Nevertheless, MHC molecules can bind thousands of different peptides and the complexity of these immunopeptidomes open the door to the study of "non-typical" peptides.Thus, some of them are posttranslationally modified peptides, spliced peptides generated by the proteasome, or peptides derived from non-canonical open reading frames.In this special Research Topic issue, we wanted to include an array of manuscripts that provides an extensive view of the alternative processing and presentation by MHC molecules and its involvement in immune disorders.A brief synopsis or each (in topical order) is included below.Building on their previously reported work, Mansurkhodzhaev et al. investigate the formation of proteasome-generated spliced zwitter peptides originating from self (human) and non-self (viral) antigens.Although such sequences can be envisioned to induce clonal deletion or other tolerance processes and restrain responses against viruses, their analysis suggests that cis-spliced peptides only marginally impinge upon functional anti-viral CD8+ cytotoxic T cell responses.In his Mini Review Münz highlights basic knowledge about how macroautophagy machinery contributes to antigen processing and presentation, strengthening its noncanonical functions, such as its role in nonconventional phagocytosis and secretion.Therefore, as argued in the manuscript, the multiple tasks played by this Frontiers in Immunology frontiersin.
Source: Frontiers in Immunology
Authors: Iñaki Alvarez, Luis C. Antón, Eddie A. James
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4296680063