Editorial: Putting engineering back in vascular tissue engineering to advance basic science and clinical applications
Year: 2022
Type: editorial
Abstract: Vascular tissue engineering can be characterized as the creation of replacement blood vessels. Over 22 the past 30 years, approaches have incorporated different combinations of extracellular matrix 23 scaffolds, cells, and active bio-chemical cues. Challenged by the goal to recapitulate the complexity of 24 big or small blood vessels, the clinical use of tissue engineered vessel replacements is still limited.With research more often focusing on reductionist materials science or cell biology characterization of 26 vessel-like constructs, an opportunity has re-emerged to apply engineering approaches to guide the 27 next step in vascular tissue engineering. The objective of this Research Topic issue is to highlight the 28 impact of "engineering," "engineering design," and "engineering design verification" in advancing the 29 design of tissue engineered blood vessels. The challenge of integrating cells, scaffolds, and bio-30 chemical cues into a functional vessel or network of vessels provokes the need to revisit design 31 requirements, the potential role of computational modeling, the opportunity for new manufacturing 32 technologies such as three-dimensional bio-printing, and the application of engineering fundamentals 33 outside the traditional materials science or cell biology tool boxes.
Authors: Walter L. Murfee, Jessica E. Wagenseil
Institutions: University of Florida, Washington University in St. Louis
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
OpenAlex ID: W4296741314