Photodynamic Inactivation of Microorganisms Using Semisynthetic Chlorophyll a Derivatives as Photosensitizers
Year: 2022
Type: article
Abstract: In this study, we describe the semisynthesis of cost-effective photosensitizers (PSs) derived from chlorophyll a containing different substituents and using previously described methods from the literature. We compared their structures when used in photodynamic inactivation (PDI) against Staphylococcus aureus, Escherichia coli, and Candida albicans under different conditions. The PSs containing carboxylic acids and butyl groups were highly effective against S. aureus and C. albicans following our PDI protocol. Overall, our results indicate that these nature-inspired PSs are a promising alternative to selectively inactivate microorganisms using PDI.
Source: Molecules
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,408
Awards: G1063147063, G1349999890, Methodologies for the synthesis of bioactive terpenes, G1548884838, Applications of technologies and synthetic methodologies developed under continuous flow conditions at LQBO-UFSCar for the preparation of molecules with biological activities and APIs, G1718254792, G2004240756, G2408843936, G295657101, G3349218969, G3436831421, G369233213, G4773289129, National Institute for Optics and Photonics, G5136177858, Facility for advanced studies of biosystems and nanostructured materials, G5649157887, G5960408532, Asymmetric photocatalysis applied to the synthesis of Brivaracetam: synthetic approaches employing enabling technologies for chemical synthesis, G6502004700, G6762759861, G7117127569, G7212092759, Cross-coupling reactions on the synthesis of new photosensitizers with high conjugation, G7539200513, G794827384, G8461143085, G8893318611
OpenAlex ID: W4296808683