Work

Formulation and Development of Adapalene Topical Nanohydrogel Using Different Surfactants and Cosurfactants for Antiacne Activity: In Vitro and Ex Vivo Evaluation

Year: 2022

Type: article

Abstract: A formulation of an adapalene nanohydrogel (ADP‐NH) using different surfactants and cosurfactants for topical application was developed and characterized. The best formulation was obtained with nanohydrogel (NH) containing Tween‐80‐ (NH‐Tween‐80‐) incorporated carbopol‐940 and ethanol, 0.67% and 3.00% w/w, respectively. The optimized formulations of NH‐Tween‐80, nanohydrogel containing sodium lauryl sulphate (NH‐SLS), and nanohydrogel containing glycerol (NH‐glycerol) were separately evaluated to examine their in vitro and ex vivo permeability characteristics and compared with 0.3% dimethyl sulfoxide (control) solution. The polydispersity index of NH‐Tween‐80, NH‐SLS, and NH‐glycerol were found to be 0.264 ± 0.312, 0.382 ± 0.0045, and 0.310 ± 0.412, respectively. All NH formulations showed pH within human skin pH ranges throughout the stability period. The NH‐Tween‐80 revealed 191.22 μg/mL of ADP permeation through Strat‐M® membrane which was statistically significant (p < 0.05) compared to NH‐SLS, NH‐glycerol, and control solution. At 24 h, NH‐Tween‐80 demonstrated 305.11 μg/mL of ADP permeation in Wistar rat abdominal skin which was 1.99‐, 1.56‐, and 4.89‐fold higher in comparison with NH‐SLS, NH‐glycerol, and control solution, respectively. Moreover, the ex vivo permeability of NH‐Tween‐80 was also compared with conventional gel (market sample) which was 3.38‐fold greater at 24 h. During the 6th month of accelerated stability analysis, the NH‐Tween‐80, NH‐SLS, and NH‐glycerol demonstrated 99.25% ± 0.15, 91.23% ± 0.41, and 96.08% ± 0.20 drug content, respectively. There were no noticeable physical changes observed up to 6 months for NH‐Tween‐80, while color change was observed in the 1st month and 3rd month of accelerated stability samples of NH‐SLS and NH‐glycerol, respectively. In this study, only NH‐Tween‐80 was considered both physically and chemically stable formulation. Therefore, it was concluded that the topical application of ADP‐NH containing Tween‐80 could be a very promising alternative for the treatment of acne vulgaris.

Source: Journal of Nanomaterials

DOI: 10.1155/2022/6889293

Authors: Vijay Kumar Panthi, Saurav Kumar Jha, Rudra Pangeni, Keshav Raj Paudel

Institutions: Tribhuvan University, Pokhara University

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,375