Single Molecule Sensing
Year: 2022
Type: book-chapter
Abstract: The dielectric nanoparties/molecules in the vicinity of a WGM microcavity evanescently perturb the WGM field. Owing to the tiny mode volume and high quality factor of the microcavity, the resulting resonance shift and spectral broadening of the microcavity’s transmission spectrum can be read-out with a high enough signal-to-noise ratio. This property has been utilized to monitor the chemical/biological reaction, such as the hybridization of DNA, and the concentration change of an analyte in an aqueous solution. Such a detection is label-free and can reach the single-molecule level by means of the localized surface plasmon resonance of metal nanoparticles. The WGM-microcavity-based sensors offer the advantages of miniaturization, simplicity, high sensitivity, and a real-time dynamic response, potentially paving a way to achieve a lab-on-a-chip sensing device.
Source: Springer eBooks
Authors: Frank Vollmer, Deshui Yu
Institution: University of Exeter
Language: English
Topic: Photonic and Optical Devices
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4296934895