Depression and Sexual Stigma Are Associated With Cardiometabolic Risk Among Sexual and Gender Minorities Living With HIV in Nigeria
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: People living with HIV are vulnerable to cardiometabolic diseases. We assessed the prevalence of cardiometabolic risk factors (CMRF) and associations with sexual stigma and depression among sexual and gender minorities (SGM) in Abuja and Lagos, Nigeria. METHODS: The TRUST/RV368 study enrolled SGM between March 2013 and February 2020. Participants were assessed for depression, sexual stigma, and CMRF. Robust multinomial logistic regression was used to estimate adjusted odds ratio (aORs) and 95% confidence intervals (CIs) for associations of depression, sexual stigma, and other factors with increasing numbers of CMRF. RESULTS: Among 761 SGM, the mean age was 25.0 ± 6.0 years; 580 (76%) identified as cisgender men, 641 (84%) had ≥1 CMRF, 355 (47%) had mild-severe depression, and 405 (53%) reported moderate-high sexual stigma. Compared with individuals without depression, those with mild (aOR 8.28; 95% CI: 4.18 to 16.40) or moderate-severe depression (aOR 41.69; 95% CI: 9.60 to 181.04) were more likely to have 3-5 CMRF. Individuals with medium (aOR 3.17; 95% CI: 1.79 to 5.61) and high sexual stigma (aOR 14.42; 95% CI: 2.88 to 72.29) compared with those with low sexual stigma were more likely to have 3-5 CMRF. Participants age 25-34 years were less likely to have 3-5 CMRF (aOR 0.41; 95% CI: 0.23 to 0.73) compared with participants age younger than 25 years. CONCLUSION: CMRF increased with severity of depression and sexual stigma, potentially predisposing SGM living with HIV to cardiometabolic diseases. Integrating interventions that address depression and sexual stigma in HIV care programs for SGM may improve cardiometabolic outcomes.
Authors: Sylvia B. Adebajo, Ruxton Adebiyi, John Chama, Segun Bello, Uche Ononaku, Abayomi Aka, Shenghan Lai, Stefan D. Baral, Typhanye V. Dyer, Trevor A. Crowell, Rebecca G. Nowak, Man Charurat, for the TRUST/RV368 Study Group
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Defense, U.S. Department of Health and Human Services, Henry M. Jackson Foundation, U.S. President’s Emergency Plan for AIDS Relief, National Institutes of Health, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Fogarty International Center
Awards: ADDRESSING THE THREATS OF HIV AND EMERGING INFECTIOUS DISEASE TO THE MILITARY AND GLOBAL COMMUNITY THROUGH INNOVATIVE RESEARCH, Validation of Stigma Metrics for Marginalized Men , G4119534169, TRUST, Epidemiology Research Training for Public Health Impact in Nigeria (Epi-Nigeria), ACTION TO CONTROL HIV EPIDEMIC THROUGH EVIDENCE (ACHIEVE), G5850682332, G6063997168, G633733221, Building TRUST, G8093122957, G8166743225, US MILITARY HIV RESEARCH, Role of anal microbiota, local cytokines and HIV in persistence of high-risk human papillomavirus, Synergistic epidemics of non-communicable diseases, stigma, depression, and material insecurities among sexual and gender minorities living with HIV in Nigeria, Leveraging Big Data Science to Focus the HIV Response in Countries with Generalized HIV Epidemics
OpenAlex ID: W4297020661