Work

Advancements in G protein‐coupled receptor biosensors to study GPCR‐G protein coupling

Year: 2022

Type: review

Abstract: Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and vary in utility, form and function. Their applications have continually expanded our understanding of this important protein class. Here, we briefly summarize a subset of this field with accelerating importance: transducer biosensors measuring receptor-coupling and selectivity, with an emphasis on sensors measuring receptor association and activation of heterotrimeric signalling complexes.

Source: British Journal of Pharmacology

DOI: 10.1111/bph.15962

Authors: Reid H. J. Olsen, Justin G. English

Institution: University of Utah

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Directed Evolution of Cell-Type Specific On-Demand Signaling Control Systems