Confirmation of fifth Candida auris clade by whole genome sequencing
Year: 2022
Type: article
Abstract: Candida auris has emerged globally as a multidrug-resistant pathogen causing outbreaks in health care facilities. Whole genome sequencing (WGS) analysis has identified four major clades, while earlier WGS data from a single Iranian isolate suggested the existence of a potential fifth clade. Here, we confirm the existence of this fifth clade by providing WGS data of another four Iranian isolates. These clade V isolates differed less than 100 single-nucleotide polymorphisms (SNPs) between each other, while they were separated from the other clades by more than 200,000 SNPs. Two of these isolates were resistant to fluconazole and were found to harbour mutations in the TAC1b and ERG11 genes.
Source: Emerging Microbes & Infections
Institutions: Radboud University Medical Center, Canisius-Wilhelmina Ziekenhuis, The University of Texas at San Antonio, Mazandaran University of Medical Sciences, Isfahan University of Medical Sciences, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Islamic Azad University Sari Branch, Babol University of Medical Sciences
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,643
OpenAlex ID: W4297229549