Year: 2022
Type: editorial
Abstract: Glomerular diseases are considered to be the result of inherited or acquired disorders and may manifest in a variety of clinical syndromes, including numerous pictures in terms of severity. A significant number of patients have no symptoms while others discover urinary abnormalities in routine screenings or they may experience low grade symptoms, such as macroscopic hematuria and edema in the lower extremities. Occasional patients present with rapidly progressive glomerulonephritis, a serious condition which may end up in advanced or end-stage kidney disease if remain untreated. Renal histopathology evaluation in combination with the characteristics of the clinical syndrome remains the cornerstone for accurate diagnosis and evidence-based treatment. During the past decade substantial progress has been made in this field, especially regarding the etiology and pathogenesis of these diseases. Recent knowledge has been added, including molecular mechanisms, genetic associations and immunologically-mediated forms of glomerulonephritis, underlining the autoimmune basis associated with genetic risk factors and environmental stimulus leading to immune-mediated injury of the glomeruli.
Source: Frontiers in Medicine
Authors: Sophia Lionaki, Vimal K. Derebail
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W4297237812