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Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

Year: 2022
Type: article
Abstract: Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non-human primate emphasize executive processes more associated with the cognitive control network (CCN) in humans. We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. To test this, we utilized human intracranial recordings of population and single unit activity targeting dorsal PCC during an alternated executive/episodic processing task. Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. Single unit recordings, however, revealed four distinct functional types with unique executive (CCN) or episodic (DMN) response profiles. Our findings provide critical electrophysiological data from human PCC, bridging incongruent views within and across species, furthering our understanding of PCC function.
Source: eLife
DOI: 10.7554/elife.80722
Authors: Lyndsey Aponik-Gremillion, Yvonne Y. Chen, Eleonora Bartoli, Seth R. Koslov, Hernan G. Rey, Kevin S. Weiner, Daniel Yoshor, Benjamin Y. Hayden, Sameer A. Sheth, Brett L. Foster
Institutions: Weber State University, Baylor College of Medicine, University of Pennsylvania, Medical College of Wisconsin, University of California, Berkeley, University of Minnesota
Language: English
Open Access status: gold
Estimated APC paid: $2,500
Awards: CAREER: Unique brain structures in human cortex: From structure to function and cognition, COGNITIVE CONTROL MECHANISMS IN HUMAN PREFRONTAL CORTEX, Sensory Reinstatement in Human Neocortex, The role of prefrontal sulcal morphology and brain network architecture in cognitive development, Multimodal dissociation of posterior cingulate cortex contributions to episodic memory, Posterior cingulate cortex and executive control of episodic memory, Naturalistic electrical stimulation strategies for effective visual cortical prostheses
OpenAlex ID: W4297458106
FWCI: 1.546
Cites: 79
Cited by: 17
Related to: 10