High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection
Year: 2022
Type: article
Abstract: gene cluster in a laboratory strain PAO1 reduced its BSI capability while overexpression of the HxuIRA pathway promoted BSI in a murine sepsis model. We further demonstrated that multiple components in the blood plasma, including heme, hemoglobin, the heme-scavenging proteins haptoglobin, and hemopexin, as well as the iron-delivery protein transferrin, could activate the Hxu system. Together, these studies suggested that the Hxu-CSS system was an important signal transduction pathway contributing to the adaptive pathogenesis of P. aeruginosa in BSI.
Source: Infection and Immunity
DOI: 10.1128/iai.00329-22
Authors: Fan Yang, Yuchen Zhou, Peishan Chen, Zeqiong Cai, Zhuo Yue, Yongxin Jin, Zhihui Cheng, Weihui Wu, Liang Yang, Un-Hwan Ha, Fang Bai
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4297459401