Year: 2022
Type: article
Abstract: Diabetes is one of the crucial health problems in this decade. Insulin secreted by β cells in the pancreatic islets of Langerhans plays a critical role in regulating the blood glucose level. Type 1 diabetes occurs as a consequence of damage to these cells or inhibition of insulin secretion in a distinctive way. Experimental type 1 diabetes can also be developed in animal species due to beta cell damage. Each animal species has specific blood glucose levels. Increasing this level at a certain rate or amount is an indication of the onset of diabetes. In various studies conducted to date, it has been demonstrated that type 1 diabetes can be established experimentally by different methods. Each type 1 diabetes management protocol has its advantages and disadvantages. The results of each protocol take place at different time intervals and depending on various factors. Different protocols are established considering various factors such as the number of animals to be used in the study and the health and nutritional status of experimental animals. Thanks to both these protocols developed and our increasing knowledge of type 1 diabetes, the production of various transgenic animals has led to significant advances in elucidating this disease and focusing on specific aspects of type 1 diabetes mellitus. This review aimed to bring together currently used type 1 diabetes models in mice.
Source: DergiPark (Istanbul University)
Authors: Gedikli, Semin, Özcan, Ali Can
Institution: Atatürk University
Language: Turkish
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4297463553