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Liquid–Liquid Phase Separation in Cardiovascular Diseases

Year: 2022
Type: review
Abstract: Liquid-liquid phase separation (LLPS) is a biochemical process in cells that can drive proteins, RNA, and other molecules to concentrate into droplets. These droplets do not have a lipid membrane but rather exist as distinct organelles relative to the surrounding environment, and act as biochemical reaction chambers. In recent years, significant progress has been made in the study of LLPS, especially in the neurodegenerative disease, cancer, and virology fields, but little is known about LLPS in cardiovascular disease (CVD). In this review, we discuss the current understanding of the mechanism and biological functions of LLPS, particularly its roles in regulating CVD.
Source: Cells
DOI: 10.3390/cells11193040
Authors: Yuanxi Mo, Yuliang Feng, Wei Huang, Ning Tan, Xinyi Li, Minwen Jie, Tong Feng, Hao Jiang, Lei Jiang
Institutions: Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, University of Oxford, University of Cincinnati, Sichuan University, West China Hospital of Sichuan University, Sun Yat-sen University, South China University of Technology
Language: English
Open Access status: gold
Estimated APC paid: $2,303
OpenAlex ID: W4297464679
FWCI: 0.624
Cites: 88
Cited by: 28
Related to: 10