Get started
Work

Protein arginine methyltransferase 1 in the generation of immune megakaryocytes: A perspective review

Year: 2022
Type: review
Abstract: Megakaryocytes (Mks) in bone marrow are heterogeneous in terms of polyploidy. They not only produce platelets but also support the self-renewal of hematopoietic stem cells and regulate immune responses. Yet, how the diverse functions are generated from the heterogeneous Mks is not clear at the molecular level. Advances in single-cell RNA seq analysis from several studies have revealed that bone marrow Mks are heterogeneous and can be clustered into 3 to 4 subpopulations: a subgroup that is adjacent to the hematopoietic stem cells, a subgroup expressing genes for platelet biogenesis, and a subgroup expressing immune-responsive genes, the so-called immune Mks that exist in both humans and mice. Immune Mks are predominantly in the low-polyploid (≤8 N nuclei) fraction and also exist in the lung. Protein arginine methyltransferase 1 (PRMT1) expression is positively correlated with the expression of genes involved in immune response pathways and is highly expressed in immune Mks. In addition, we reported that PRMT1 promotes the generation of low-polyploid Mks. From this perspective, we highlighted the data suggesting that PRMT1 is essential for the generation of immune Mks via its substrates RUNX1, RBM15, and DUSP4 that we reported previously. Thus, we suggest that protein arginine methylation may play a critical role in the generation of proinflammatory platelet progeny from immune Mks, which may affect many immune, thrombotic, and inflammatory disorders.
DOI: 10.1016/j.jbc.2022.102517
Authors: Xinyang Zhao, Zechen Chong, Yabing Chen, X. Long Zheng, Qian-Fei Wang, Yueying Li
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,500
Funders: National Natural Science Foundation of China, Natural Science Foundation of Beijing Municipality, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Molecular Mechanisms Regulating Endothelial Dysfunction, Regulation of vascular smooth muscle cell function in atherosclerosis, G6393069620, Molecular Mechanisms Governing Vascular Cell Function and Phenotype in Health and Disease, G7217850380, G7670815060, The Functions of antisense RNA AS-RBM15 in hematopoiesis, Advanced genome and transcriptome analysis using long-read sequencing technologies
OpenAlex ID: W4297880445
FWCI: 0.268
Cites: 94
Cited by: 6
Related to: 10