Work

Mitochondria as the memory of preconditioning.

Year: 2021

Type: article

Abstract: , and ROS scavenging. We will also discuss how aging impacts mitochondria and the consequences of mitochondrial aging on preconditioning mechanisms. We will concentrate on the regulation of mitochondrial DNA content and quantification specifically for its value as a biomarker to monitor disease conditions. The identification of these mitochondrial preconditioning mechanisms can be translated to potential pharmacological interventions to increase intrinsic resilience of the brain to injury and to develop novel approaches to neurodegenerative diseases. Moreover, mitochondria dynamics can be used as a memory or biomarker of preconditioning.

Source: PubMed

Authors: Sarah Zerimech, Hung Nguyen, Selva Baltan

Institution: Oregon Health & Science University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: Vulnerability of Aging White Matter to Ischemia, Casein kinase 2 signaling in axonal injury, Vulnerability of Aging White Matter to Ischemia