A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Year: 2020
Type: article
Abstract: Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry, and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one novel locus at 5q33 (GALNT10, rs7708584, p=3.4×10−11) and another at 7p15 when combined with data from the Giant consortium (MIR148A/NFE2L3, rs10261878, p=1.2×10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African ancestry sample (KLHL32, rs974417, p=6.9×10−8). Thirty-two of the 36 previously established BMI variants displayed directionally consistent effect estimates in our GWAS (binomial p=9.7×10−7), of which five reached genome-wide significance. These findings provide strong support for shared BMI loci across populations as well as for the utility of studying ancestrally diverse populations.
DOI: 10.17615/sjav-aa47
Authors: Yanek, Lisa R, Broeckel, Ulrich, Sun, Yan V, Palmer, Cameron, Adeyemo, Adebowale A, Liu, Yongmei, Britton, Angela, Bandera, Elisa V, Caporaso, Neil E, Edwards, Todd L, Ng, Maggie C Y, Bock, Cathryn H, Graff, Mariaelisa, Monda, Keri L, Chen, Guanjie, Rhie, Suhn K, Cai, Quiyin, Taylor, Kira C, Ademola, Adeyinka, Bielak, Lawrence F, Allison, Matthew A, Lu, Yingchang, Li, Guo, Irvin, Marguerite R, Lange, Leslie A, Wojczynski, Mary K, Nalls, Michael A, Carlson, Chris S, Liu, Youfang, Aldrich, Melinda C, Amos, Christopher I, Chen, Gary K
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4297927579