Work

A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen

Year: 2020

Type: article

Abstract: Gene expression profiling classifies breast cancer into intrinsic subtypes based on the biology of the underlying disease pathways. We have used material from a prospective randomized trial of tamoxifen versus placebo in premenopausal women with primary breast cancer (NCIC CTG MA.12) to evaluate the prognostic and predictive significance of intrinsic subtypes identified by both the PAM50 gene set and by immunohistochemistry.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/wqhx-w950

Authors: Tu, Dongsheng, Bernard, Philip S., Mardis, Elaine, Chia, Stephen K., Shepherd, Lois E., Perou, Charles M., Nielsen, Torsten O., Parker, Joel S., Leung, Samuel, Pritchard, Kathleen I., Vickery, Tammi, Ung, Karen, Bramwell, Vivien H., Ellis, Matthew J., Jiang, Shan

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4297953007

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