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Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial

Year: 2020
Type: article
Study design: Clinical Trial
Abstract: In Africa, most plasmodium infections during pregnancy remain asymptomatic, yet are associated with maternal anemia and low birthweight. WHO recommends intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP). However, sulfadoxine-pyrimethamine (SP) efficacy is threatened by high-level parasite resistance. We conducted a trial to evaluate the efficacy and safety of scheduled intermittent screening with malaria rapid diagnostic tests (RDTs) and treatment of RDT-positive women with dihydroartemisinin-piperaquine (DP) as an alternative strategy to IPTp-SP.
DOI: 10.17615/4fzt-j921
Authors: Kalilani, Linda, Levitt, Brandt, Madanitsa, Mwayiwawo, Kang’ombe, Arthur, Khairallah, Carole, Smedley, James, Thwai, Kyaw-Lay, Wang, Duolao, Taylor, Steve M., Faragher, Brian, Mwapasa, Victor, van Eijk, Anna M., ter Kuile, Feiko O., Meshnick, Steve, Pace, Cheryl, Ali, Doreen
Language: English
Field: Medicine
Open Access status: green
Funders: Bill and Melinda Gates Foundation, University of Washington, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
OpenAlex ID: W4297953294
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