Work

Polycyclic aromatic hydrocarbon (PAH)–DNA adducts and breast cancer: modification by gene promoter methylation in a population-based study

Year: 2020

Type: article

Study design: Observational Study

Abstract: Polycyclic aromatic hydrocarbons (PAH)-DNA adducts have been associated with breast cancer incidence. Aberrant changes in DNA methylation may be an early event in carcinogenesis. However, possible relations between PAH-DNA adducts, methylation and breast cancer are unknown. The objectives of this study were to (1) assess associations between PAH-DNA adducts and breast cancer, stratified by DNA methylation markers; and, (2) to examine interactions between adducts and DNA methylation in association with breast cancer and tumor subtype.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/a9qf-tw11

Authors: White, Alexandra J., Neugut, Alfred I., Hibshoosh, Hanina, Santella, Regina M., Gammon, Marilie D., Terry, Mary Beth, Teitelbaum, Susan L., Cho, Yoon Hee, McCullough, Lauren E., Xu, Xinran, Chen, Jia

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences

Awards: G1929001646, G232130970, G4119534169, A POPULATION-BASED STUDY OF ONE-CARBON METABOLISM AND BREAST CANCER SURVIVAL, G5850682332, Dietary Methyl Content, Epigenetics and Breast Cancer, G9000032209, G9000147072, G9000340854, Cancer Center Support Grant, Center for Environmental Health in Northern Manhattan

OpenAlex ID: W4297971397

FWCI:

Cites:

Cited by:

Related to: 10