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Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer

Year: 2020
Type: article
Abstract: Obesity is associated with increased bioavailability of estrogen, hyperinsulemia and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic variation in these pathways may modify the obesity-postmenopausal breast cancer association.
DOI: 10.17615/pcf3-x561
Authors: Neugut, Alfred I., Gammon, Marilie D., Terry, Mary Beth, Ambrosone, Christine B., Ahn, Jiyoung, Santella, Regina M., Cleveland, Rebecca J., Bradshaw, Patrick T., Rossner, Pavel, Eng, Sybil M., McCullough, Lauren E., Steck, Susan E., Crew, Katherine D., Teitelbaum, Susan L., Shen, Jing
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
OpenAlex ID: W4297984818
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Related to: 10