Biological, clinical and population relevance of 95 loci for blood lipids
Year: 2010
Type: article
Study design: Observational Study
Source: Nature
DOI: 10.1038/nature09270
Authors: Tanya M. Teslovich, Kiran Musunuru, Albert V. Smith, Andrew C. Edmondson, Ioannis M. Stylianou, Masahiro Koseki, James P. Pirruccello, Samuli Ripatti, Daniel I. Chasman, Cristen J. Willer, Christopher T. Johansen, Sigrid W. Fouchier, Aaron Isaacs, Gina M. Peloso, Maja Barbalic, Sally L. Ricketts, Joshua C. Bis, Yurii S. Aulchenko, Gudmar Thorleifsson, Mary F. Feitosa, John Chambers, Marju Orho-Melander, Olle Melander, Toby Johnson, Xiaohui Li, Xiuqing Guo, Mingyao Li, Yoon Shin Cho, Min Jin Go, Young Jin Kim, Jong-Young Lee, Taesung Park, Kyunga Kim, Xueling Sim, Rick Twee-Hee Ong, Damien C. Croteau-Chonka, Leslie A. Lange, Joshua D. Smith, Kijoung Song, Jing Hua Zhao, Xin Yuan, Jian’an Luan, Claudia Lamina, Andreas Ziegler, Weihua Zhang, Robert Y. L. Zee, Alan F. Wright, Jacqueline C. M. Witteman, James F. Wilson, Gonneke Willemsen, H.-Erich Wichmann, John B. Whitfield, Dawn M. Waterworth, Nicholas J. Wareham, Gérard Waeber, Peter Vollenweider, Benjamin F. Voight, Veronique Vitart, Andre G. Uitterlinden, Manuela Uda, Jaakko Tuomilehto, John R. Thompson, Toshiko Tanaka, Ida Surakka, Heather M. Stringham, Tim D. Spector, Nicole Soranzo, Johannes H. Smit, Juha Sinisalo, Kaisa Silander, Eric J. G. Sijbrands, Angelo Scuteri, James Scott, David Schlessinger, Serena Sanna, Veikko Salomaa, Juha Saharinen, Chiara Sabatti, Aimo Ruokonen, Igor Rudan, Lynda M. Rose, Robert Roberts, Mark Rieder, Bruce M. Psaty, Peter P. Pramstaller, Irene Pichler, Markus Perola, Brenda W. J. H. Penninx, Nancy L. Pedersen, Cristian Pattaro, Alex N. Parker, Guillaume Pare, Ben A. Oostra, Christopher J. O’Donnell, Markku S. Nieminen, Deborah A. Nickerson, Grant W. Montgomery, Thomas Meitinger, Ruth McPherson, Mark I. McCarthy, Wendy McArdle, David Masson, Nicholas G. Martin, Fabio Marroni, Massimo Mangino, Patrik K. E. Magnusson, Gavin Lucas, Robert Luben, Ruth J. F. Loos, Marja-Liisa Lokki, Guillaume Lettre, Claudia Langenberg, Lenore J. Launer, Edward G. Lakatta, Reijo Laaksonen, Kirsten O. Kyvik, Florian Kronenberg, Inke R. König, Kay-Tee Khaw, Jaakko Kaprio, Lee M. Kaplan, Åsa Johansson, Marjo-Riitta Jarvelin, A. Cecile J. W. Janssens, Erik Ingelsson, Wilmar Igl, G. Kees Hovingh, Jouke-Jan Hottenga, Albert Hofman, Andrew A. Hicks, Christian Hengstenberg, Iris M. Heid, Caroline Hayward, Aki S. Havulinna, Nicholas D. Hastie, Tamara B. Harris, Talin Haritunians, Alistair S. Hall, Ulf Gyllensten, Candace Guiducci, Leif C. Groop, Elena Gonzalez, Christian Gieger, Nelson B. Freimer, Luigi Ferrucci, Jeanette Erdmann, Paul Elliott, Kenechi G. Ejebe, Angela Döring, Anna F. Dominiczak, Serkalem Demissie, Panagiotis Deloukas, Eco J. C. de Geus, Ulf de Faire, Gabriel Crawford, Francis S. Collins, Yii-der I. Chen, Mark J. Caulfield, Harry Campbell, Noel P. Burtt, Lori L. Bonnycastle, Dorret I. Boomsma, S. Matthijs Boekholdt, Richard N. Bergman, Inês Barroso, Stefania Bandinelli, Christie M. Ballantyne, Themistocles L. Assimes, Thomas Quertermous, David Altshuler, Mark Seielstad, Tien Y. Wong, E-Shyong Tai, Alan B. Feranil, Christopher W. Kuzawa, Linda S. Adair, Herman A. Taylor Jr, Ingrid B. Borecki, Stacey B. Gabriel, James G. Wilson, Hilma Holm, Unnur Thorsteinsdottir, Vilmundur Gudnason, Ronald M. Krauss, Karen L. Mohlke, Jose M. Ordovas, Patricia B. Munroe, Jaspal S. Kooner, Alan R. Tall, Robert A. Hegele, John J.P. Kastelein, Eric E. Schadt, Jerome I. Rotter, Eric Boerwinkle, David P. Strachan, Vincent Mooser, Kari Stefansson, Muredach P. Reilly, Nilesh J Samani, Heribert Schunkert, L. Adrienne Cupples, Manjinder S. Sandhu, Paul M Ridker, Daniel J. Rader, Cornelia M. van Duijn, Leena Peltonen, Gonçalo R. Abecasis, Michael Boehnke, Sekar Kathiresan
Institutions: University of Michigan, Broad Institute, Harvard University, Johns Hopkins University, Massachusetts General Hospital, University of Iceland, Icelandic Heart Association, University of Pennsylvania, Columbia University, University of Helsinki, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland, Brigham and Women's Hospital, Western University, Robarts Research Institute, Amsterdam UMC Location University of Amsterdam, University of Amsterdam, Erasmus MC, Boston University, Framingham Heart Study, The University of Texas Health Science Center at Houston, University of Cambridge, University of Washington, deCODE Genetics (Iceland), Washington University in St. Louis, Imperial College London, Lund University, Queen Mary University of London, William Harvey Research Institute, Cedars-Sinai Medical Center, Korea National Institute of Health, Seoul National University, Sookmyung Women's University, National University of Singapore, Genome Institute of Singapore, University of North Carolina at Chapel Hill, GlaxoSmithKline (United States), Addenbrooke's Hospital, MRC Epidemiology Unit, Innsbruck Medical University, Universität Innsbruck, University of Lübeck, Institute of Genetics and Cancer, MRC Human Genetics Unit, Centre for Medical Systems Biology, Netherlands Consortium for Healthy Ageing, University of Edinburgh, Vrije Universiteit Amsterdam, Helmholtz Munich, QIMR Berghofer Medical Research Institute, Centre Hospitalier Universitaire Vaudois, Institute of Genetic and Biomedical Research, National Research Council, University of Leicester, National Institutes of Health, National Institute on Aging, MedStar Health Research Institute, King's College London, Wellcome Sanger Institute, Amsterdam Neuroscience, Amsterdam UMC Location Vrije Universiteit Amsterdam, Helsinki University Hospital, Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale di Riposo e Cura per Anziani, Hammersmith Hospital, Stanford University, University of Oulu, University of Ottawa, Group Health Cooperative, Eurac Research, Karolinska Institutet, Amgen (United States), McMaster University, TUM Klinikum, Institut für Humangenetik, Technical University of Munich, Centre for Human Genetics, Churchill Hospital, University of Oxford, NIHR Oxford Biomedical Research Centre, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Bristol, Istituto di Genomica Applicata, Municipal Institute for Medical Research, Montreal Heart Institute, Université de Montréal, Tampere University Hospital, University of Southern Denmark, Uppsala University, University of Regensburg, Aalto University, University of Leeds, University of California, Los Angeles, University of Glasgow, National Human Genome Research Institute, University of Southern California, Azienda Sanitaria di Firenze, Baylor College of Medicine, Stanford Medicine, Singapore Eye Research Institute, University of San Carlos, Northwestern University, University of Mississippi Medical Center, Tufts University, United States Department of Agriculture, Spanish National Centre for Cardiovascular Research, Jean Mayer Human Nutrition Research Center on Aging, Sage Bionetworks, St George's, University of London, Glenfield Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: GlaxoSmithKline, Wellcome Trust, British Heart Foundation, National Institutes of Health, U.S. Public Health Service, Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1023702118, G1036572533, G10717269, Women's Health Study: Continued Follow-Up, G1137313802, G118440752, Carolina Population Center, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G136105103, Mapping Adiposity QTLS in the NHLBI Family Heart Study, G1462415530, CHS-ULTRASOUND READING, G1567724564, G15705064, THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1660689499, G178033515, G1789099407, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, G1909643007, Genetic Epidemiology of Body Mass Index, Adiposity and Weight Gain, G1968135291, G210849167, G2111339113, Atherosclerosis Risk in Communities Study (ARIC), G215333750, Targeted Genetic Analysis of T2D and Quantitative Traits, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G227387708, G230712557, Genetic analysis of type II diabetes in Finnish population, Institute for Clinical and Translational Research (UL1), G250621538, CCSP FIELD CENTER, G2553430561, G25881238, Molecular mechanisms and pathways of novel genomic loci regulating plasma lipids, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, COMMUNITY AND COHORT SURVEILLANCE PROGRAM, G270907595, Genome-wide association study of HDL: linking genetic loci for HDL to risk of coronary artery disease, G277826483, G2800149121, CENTRAL HEMOSTATIS LABORATORY FOR CCSP, G2818913090, Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and ‘hypercontrols’, Identifying Genes for Type 2 Diabetes: FUSION, A Genome-wide Association Study for Early-Onset Myocardial Infarction, WGA Study to Identify Genetic Variants Associated with CV Events in CHS, GENOTYPING FOR LOCATING HUMAN DISEASE GENES, Genetics of Elevated High Density Lipoprotein Cholesterol, G34347772, Genetic Epidemiology of Metabolic Diseases of Obesity, G36937976, GWA for Gene-Environment Interaction Effects Influencing CHD, NRSA in Genetics, G3897472563, G395403786, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, FHS-SCAN Genome Wide Association Scan for Atherosclerosis Pathway Genes, G4050880153, G423252844, Atherosclerosis Risk in Communities Study (ARIC), LEVEL OF ACE INHIBITION IN HEART FAILURE, Pharmacogenomics and Risk of Cardiovascular Disease, RENEWAL: Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies, G4987078009, Genetics of cardiovascular risk factors in large founder population birth control, G528395701, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, Genetic Variants Associated with HDL and LDL Cholesterol, and Triglyceride Levels, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G558986044, GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS, G5616273554, Atherosclerosis Risk in Communities Study (ARIC), G590700339, CHS Events Follow-up Study, G6008908520, G6206675870, G627116550, G633297803, Type 1 Diabetes Genetics Consortium, The Framingham Heart Study, GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCAN, An Interdisciplinary Strategy for Obesity (RMI), An NCRR Center for High Throughput SNP Genotyping and Analysis, G6613352697, CHS-Transition Phase, G6744579632, Genetic and functional analyses of a novel locus associated with LDL-C and MI, Cambridge Institute for Medical Research (CIMR)., Obesity development and CVD risk factor clustering in Filipino women & offspring, G7197155317, Effect of Health on Education &Work in Filipino Youth, CHS RETINAL READING CENTER, General Clinical Research Center, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G775909998, G786153652, Genetic Risk Stratification to Identify Individuals for Early Statin Therapy, Women's Health Study: Continued Follow-up, G793702358, G8123125509, G8126692777, Identification of Causal Variants at Novel GWAS Loci Associated with Lipid Traits, G853394594, Genome-wide association study of MI in Caucasians, Building on GWAS for NHLBI-disease: the CHARGE consortium, University of Michigan Training Program in Genomic Science, UNC Center for Environmental Health and Susceptibility, Diabetes Research Center (DRC), Nutrition Obesity Research Center (NORC), Integrated, Multidisciplinary Training in Cardiovascular Research, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, G905887895, G936067872, G939135972, G960597250, Atherosclerosis Risk in Communities Study (ARIC)
OpenAlex ID: W2115801316