A peek at the other side of the coin: Tumor‐suppressor role of microRNAs expressed by pancreatic cancer‐associated fibroblasts
Year: 2023
Type: article
Abstract: Cancer-associated fibroblast (CAF) is abundant in the tumor microenvironment (TME) and broadly accepted as an oncogenic component for pancreatic ductal adenocarcinoma (PDAC). We previously reported a tumor-suppressive role of CAFs via a CAF-specific miRNA that can be efficiently transferred via exosomes within the TME and inhibit PDAC cell growth. In this study, we expanded our search and found several differentially expressed miRNAs within CAFs (CAF-DE-miRNAs) including the most elevated miR-145-5p and miR-199a-5p. These miRNAs exhibit tumor-suppressive roles likely via complex regulation of several signaling proteins within the TGF-β and EGFR (ErbB) signaling pathways. Our study indicates a more complex role of CAFs within the TME and provides a distinct mechanism of CAF-mediated tumor suppression.
DOI: 10.1002/ctm2.1357
Institutions: University of Florida Health, University of Florida
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,300
Awards: G4111989264, U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERS, Training Program for Applied Research and Development in Genomic Medicine, Exploring novel therapeutic strategies for combinatory therapy to treat renal clear cell carcinomas, Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis
OpenAlex ID: W4385564701