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Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

Year: 2020
Type: article
Abstract: Tumor cell tissue factor (TF)-initiated coagulation supports hematogenous metastasis by fibrin formation, platelet activation, and monocyte/macrophage recruitment. Recent studies identified host anticoagulant mechanisms as a major impediment for successful hematogenous tumor cell metastasis.
DOI: 10.17615/g71y-sp71
Authors: Ruggeri, Z. M., Ellies, L. G., Yokota, N., Mackman, N., Zarpellon, A., Gruber, A., Castellino, F. J., Ruf, W., Weiler, H., Bogdanov, V. Y., Chakrabarty, S.
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: green
OpenAlex ID: W4298172890
FWCI:
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